Tuesday, January 15, 2013

Renal allografts with chronic lesions in early biopsies

Chronic Histological Damage in Early Indication Biopsies Is an Independent Risk Factor for Late Renal Allograft Failure

The study shows that chronic histological lesions are inherently bad for the kidney grafts biopsied for causes within 1 yr after transplant. On multivariate analysis arteriolar hyalinosis and transplant glomerulopathy were associated with graft survival while others such as interstitial fibrosis were not. However,all the chronic lesions occurred together and were collectively impacted graft survival. The study emphasizes the impact of chronic lesions on graft regardless of the etiology.