Collapsing glomerulopathy (CG) can be primary or secondary to a number of conditions such as HIV infection. It is commonly agreed that the podocyte injury is the underlying etiology, hence the name podocytopathy. Salvatore et al. studied this lesion in patients with diabetic nephropathy (DN). There were CG in 30 of 534 biopsies with diabetic nephropathy. The patients with DN and CG had higher level of proteinuria and were more likely to progress to end stage renal disease than patients with DN only. The podocytes in patients with CG showed absence or decrease of maturation markers such as WT-1, synptopodin. Severe arteriosclerosis and arteriolar hyalinosis were noted in this group of patients. The authors suggested ischemic injury to podocytes as the cause of CG in DN.
Monday, March 24, 2014
Collapsing glomerulopathy superimposed on diabetic nephropathy: insights into etiology of an under-recognized, severe pattern of glomerular injury
Collapsing glomerulopathy (CG) can be primary or secondary to a number of conditions such as HIV infection. It is commonly agreed that the podocyte injury is the underlying etiology, hence the name podocytopathy. Salvatore et al. studied this lesion in patients with diabetic nephropathy (DN). There were CG in 30 of 534 biopsies with diabetic nephropathy. The patients with DN and CG had higher level of proteinuria and were more likely to progress to end stage renal disease than patients with DN only. The podocytes in patients with CG showed absence or decrease of maturation markers such as WT-1, synptopodin. Severe arteriosclerosis and arteriolar hyalinosis were noted in this group of patients. The authors suggested ischemic injury to podocytes as the cause of CG in DN.
