Membranous-like glomerulopathy with masked IgG kappa deposits (MGMID) is a glomerular disease defined by its pattern of injury. While the pathogenesis is unknown, the disease was mostly found in young females without paraproteinemia. Serum amyloid P (SAP) is recently identified as defining characteristic of MGMID. By mass spectrometry, the protein was abundant in glomeruli from MGMID patients. Immunostaining showed all MGMID patients positive for SAP.
SAP is a multifunctional serum protein with anti-autoimmunity role. Its role in pathogenesis of MGMID is uncertain.
https://doi.org/10.1016/j.kint.2019.10.026
